Comparison of seroconversion rates between low-dose intradermal and recommended dose intramuscular hepatitis B vaccination in children

• Main Authors: Sony HA Harsono (Author), Zarkasih Anwar (Author), Nancy Pardede (Author)
• Format: Book
• Published: Indonesian Pediatric Society Publishing House, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Introduction Massive hepatitis B vaccination is expensive. Re- sults of studies showed that reduced dosage given intradermally to adults and intramuscularly to children were able to induce seroconversion. Objective To compare the anti-HBs seroconversion (seropositive and seroprotective) rates between intradermal low-dose of 2 mg (ID-2) and intramuscular recommended dose of 10 mg (IM-10) vaccination against hepatitis B. Methods In a randomized clinical trial, using the hepatitis B plasma vaccine, elementary school children in Tanjung Enim subdistrict, 80-168 months of age, were randomly assigned to be given three doses of either the ID-2 (n=59) or IM-10 (n=64) vaccinations at one month intervals. Seropositive (anti HBs titer >2.1 mIU/l) and seroprotective (anti HBs >10 mIU/l) rates as well as the seroposi- tive and seroprotective geometric mean antibody titers (GMTs) were compared one month after each inoculation. A p value of <0.1 was considered statistically significant. Results One month after the third inoculation, there was no sig- nificant difference in the seropositive rate (95% vs. 89%), seroprotective rate (85% vs. 83%), seropositive GMTs (55.85 mIU/ l vs. 61.24mIU/l), and seroprotective GMTs (73.86 mIU/l vs. 72.49 mIU/l) between the ID-2 and the IM-10 groups (all with p>0.1) Conclusion Reduced doses of the hepatitis B vaccine given in- tradermally may offer protection against hepatitis B, thus it may be useful for mass vaccination programs

Item Description

0030-9311
2338-476X
10.14238/pi43.4.2003.140-6