Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function

• Main Authors: Alba Vera-Zambrano (Author), Maria Baena-Nuevo (Author), Susanne Rinné (Author), Marta Villegas-Esguevillas (Author), Bianca Barreira (Author), Gokcen Telli (Author), Angela de Benito-Bueno (Author), José Antonio Blázquez (Author), Belén Climent (Author), Francisco Pérez-Vizcaino (Author), Carmen Valenzuela (Author), Niels Decher (Author), Teresa Gonzalez (Author), Angel Cogolludo (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

KV1.5 channels are key players in the regulation of vascular tone and atrial excitability and their impairment is associated with cardiovascular diseases including pulmonary arterial hypertension (PAH) and atrial fibrillation (AF). Unfortunately, pharmacological strategies to improve KV1.5 channel f...