New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of Nanoparticle Cytotoxicity

• Main Authors: Vladimir Panov (Author), Tatiana Bushueva (Author), Ilzira Minigalieva (Author), Anna Naumova (Author), Vladimir Shur (Author), Ekaterina Shishkina (Author), Marina Sutunkova (Author), Vladimir Gurviсh (Author), Larisa Privalova (Author), Boris Katsnelson (Author)
• Format: Book
• Published: SAGE Publishing, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Spherical selenium-oxide and copper-oxide nanoparticles (SeO-NP with mean diameter 51 ± 14 nm and CuO-NP with mean diameter 21 ± 4 nm) were found to be cytotoxic for human fibroblast-like cells in vitro, as judged by decreased ATP-dependent luminescence. Compared with SeO-NP, CuO-NP produced a somewhat stronger effect of this kind. Along with cell hypertrophy developing in response to certain doses of SeO-NP and CuO-NP, our experiment also revealed doses causing a decrease in cell and cell-nucleus sizes. We observed both monotonic and different variants of nonmonotonic dose-response relationship. For the latter, we have succeeded in constructing adequate mathematical expressions based on the generalized hormesis paradigm that we had considered previously in respect of CdS-NP and PbS-NP cytotoxicity for cardiomyocites. It was demonstrated as well that combined toxicity of SeO-NP and CuO-NP is of different types depending on the outcome.

Item Description

1559-3258
10.1177/15593258211052420