Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19

No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction. Impairment in immunity activation in some patients, mo...

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Bibliographic Details
Main Authors: Pouria Mosaddeghi (Author), Farbod Shahabinezhad (Author), Mohammadreza Dorvash (Author), Mojtaba Goodarzi (Author), Manica Negahdaripour (Author)
Format: Book
Published: Taylor & Francis Group, 2021-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Pouria Mosaddeghi  |e author 
700 1 0 |a Farbod Shahabinezhad  |e author 
700 1 0 |a Mohammadreza Dorvash  |e author 
700 1 0 |a Mojtaba Goodarzi  |e author 
700 1 0 |a Manica Negahdaripour  |e author 
245 0 0 |a Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19 
260 |b Taylor & Francis Group,   |c 2021-06-01T00:00:00Z. 
500 |a 2164-5515 
500 |a 2164-554X 
500 |a 10.1080/21645515.2020.1833577 
520 |a No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction. Impairment in immunity activation in some patients, mostly elderlies, leads to high mortalities; thus, promoting immune responses may help. BCG vaccine is under investigation to prevent COVID-19 due to its non-specific effects on the immune system. However, other complementary immune-induction methods at early stages of the disease may be needed. Here, the potentially preventive immunologic effects of BCG and influenza vaccination are compared with the immune response defects caused by aging and COVID-19. BCG co-administration with interferon-α/-β, or influenza vaccine is suggested to overcome its shortcomings in interferon signaling against COVID-19. However, further studies are highly recommended to assess the outcomes of such interventions considering their probable adverse effects especially augmented innate immune responses and overproduction of proinflammatory mediators. 
546 |a EN 
690 |a covid-19 
690 |a bcg vaccine 
690 |a influenza vaccine 
690 |a immunity 
690 |a pandemic 
690 |a trained immunity 
690 |a severe acute respiratory syndrome coronavirus 2 
690 |a Immunologic diseases. Allergy 
690 |a RC581-607 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Human Vaccines & Immunotherapeutics, Vol 17, Iss 6, Pp 1650-1661 (2021) 
787 0 |n http://dx.doi.org/10.1080/21645515.2020.1833577 
787 0 |n https://doaj.org/toc/2164-5515 
787 0 |n https://doaj.org/toc/2164-554X 
856 4 1 |u https://doaj.org/article/66b3a0c11b564caeaf2e7a26ca5f1b6f  |z Connect to this object online.