Spectrophotometric Determination of Mesalazine Via Arsenazo III- Cerium(III) Reaction
Abstract<br /> A simple and sensitive spectrophotometric method has been developed for the determination of mesalazine (5-aminosalicylic acid) in pure form and in its pharmaceutical preparation(capsule). The method is based on the oxidation-reduction reaction between mesalazine and cerium (IV)...
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| Format: | Book |
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College of Education for Pure Sciences,
2011-03-01T00:00:00Z.
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| Summary: | Abstract<br /> A simple and sensitive spectrophotometric method has been developed for the determination of mesalazine (5-aminosalicylic acid) in pure form and in its pharmaceutical preparation(capsule). The method is based on the oxidation-reduction reaction between mesalazine and cerium (IV) ion, then reaction of cerium(III) with arsenazo III reagent in acidic medium to produce a green-blue complex, which is stable, water soluble and has a maximum absorption at 654 nm with a molar absorptivity of 2.103×105 l.mol-1.cm -1. Beerُ s law is obeyed in the concentration range of 0.5 to 14 µg of mesalazine in a final volume of 25 ml. The proposed method has been applied successfully for determination of mesalazine in pharmaceutical preparation (capsule). |
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| Item Description: | 1812-125X 2664-2530 10.33899/edusj.2011.51507 |