Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience
Background: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR). Aim: To validate of serum SeP as a measure for insulin resistance in patients with type 1 diabetes m...
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Cairo University, Faculty of Medicine, Department of Pediatrics,
2022-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_670ee23da4a145a59bcc6e567a3b49d7 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hend Mehawed Soliman |e author |
| 700 | 1 | 0 | |a Balsam Sherif Fahmy |e author |
| 700 | 1 | 0 | |a Selim Mohamed Abdelkader |e author |
| 700 | 1 | 0 | |a Samah A. Hassanein |e author |
| 245 | 0 | 0 | |a Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience |
| 260 | |b Cairo University, Faculty of Medicine, Department of Pediatrics, |c 2022-01-01T00:00:00Z. | ||
| 500 | |a 10.21608/cupsj.2021.108303.1040 | ||
| 500 | |a 2805-279X | ||
| 500 | |a 2682-3985 | ||
| 520 | |a Background: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR). Aim: To validate of serum SeP as a measure for insulin resistance in patients with type 1 diabetes mellitus (T1DM). Methods: This prospective case-control study included 45 children and adolescents with T1DM and 45 healthy children and adolescents. Serum SeP was measured by ELISA and compared to estimated glucose disposal rate (eGDR) as a measure of insulin resistance. Results: Mean ± SD of SeP level was higher in T1DM patients than control group (59.78 ± 59.38 ng/ml, 55.57 ± 7.6 ng/ml,respectively), this difference was statistically insignificant (p= 0.642). SeP demonstrated significant positive correlations with duration of diabetes (r=0.413, p=0.005), high density lipoproteins (r=0.496, p=0.001) and glycosylated hemoglobin (r=0.357, p=0.016). There were statistically significant differences in eGDR between cases and controls (7.78±3.08 mg/kg/min, 12.53±0.91mg/kg/min, respectively, (p= 0.001). There was no correlation between SeP level and eGDR values (IR indicator). Conclusion: Serum SeP level in T1DM patients was not indicative of IR. Higher serum SeP level are associated with longer duration and poor control of T1DM. | ||
| 546 | |a EN | ||
| 690 | |a diabetes mellitus | ||
| 690 | |a insulin resistance | ||
| 690 | |a selenoprotein p | ||
| 690 | |a estimated glucose disposal rate. | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pediatric Sciences Journal, Vol 2, Iss 1, Pp 32-38 (2022) | |
| 787 | 0 | |n https://cupsj.journals.ekb.eg/article_210817_6154945413a3fbb41f5f250878c93483.pdf | |
| 787 | 0 | |n https://doaj.org/toc/2805-279X | |
| 787 | 0 | |n https://doaj.org/toc/2682-3985 | |
| 856 | 4 | 1 | |u https://doaj.org/article/670ee23da4a145a59bcc6e567a3b49d7 |z Connect to this object online. |