Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

• Main Authors: Jana Van Dycke (Author), Michela Puxeddu (Author), Giuseppe La Regina (Author), Eloise Mastrangelo (Author), Delia Tarantino (Author), Jasper Rymenants (Author), Jessica Sebastiani (Author), Marianna Nalli (Author), Jelle Matthijnssens (Author), Johan Neyts (Author), Romano Silvestri (Author), Joana Rocha-Pereira (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting in ~219,000 deaths annually and a societal cost of ~USD60 billion. There are no antivirals or vaccines available to treat and/or prevent HuNoV. In this study, we performed a large-scale phenotypical antiviral scr...