Pharmacokinetic-Pharmacometabolomic Approach in Early-Phase Clinical Trials: A Way Forward for Targeted Therapy in Type 2 Diabetes

• Main Authors: Khim Boon Tee (Author), Luqman Ibrahim (Author), Najihah Mohd Hashim (Author), Mohd Zuwairi Saiman (Author), Zaril Harza Zakaria (Author), Hasniza Zaman Huri (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacometabolomics in early phase clinical trials demonstrate the metabolic profiles of a subject responding to a drug treatment in a controlled environment, whereas pharmacokinetics measure the drug plasma concentration in human circulation. Application of the personalized peak plasma concentrati...