Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae)

• Main Authors: Emmanuel Ifeanyi Attah (Author), Samson Chibuzo Ugwuagbo (Author), Sampath Chinnam (Author), Fabian Ifeanyi Eze (Author), Charles Okeke Nnadi (Author), Matthias Onyebuchi Agbo (Author), Wilfred Obonga (Author), Mithun Rudrapal (Author), Sanjay G. Walode (Author), Aatika Nizam (Author), Ranjan Kumar Sahoo (Author), Atul R. Bendale (Author), Shubham J. Khairnar (Author), Mohini R. Jagtap (Author)
• Format: Book
• Published: Pensoft Publishers, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Over the years, medicinal plants have been employed in the treatment of inflammation and related ailments. This study evaluated the anti-inflammatory potential of the aerial parts of S. brevipes. The extracts and fractions were further evaluated for anti-inflammatory activity in carrageenan-induced rat model at varying doses (200 and 400 mg/kg doses, orally) for 5 h of treatment. The result of the phytochemical screening showed the presence of alkaloids, terpenoids, glycosides, flavonoids and tannins in the aerial parts of the plant. The in vivo anti-inflammatory study exhibited inhibition of 42% and 44%, 47% and 36%, 33% and 31%, and 43% and 42% for methanol extract n-hexane fraction, ethyl acetate fraction, and methanol fraction, at 200 and 400 mg/kg doses, respectively. The positive control (diclofenac sodium) showed an inhibition value of 51% at 5 mg/kg dose. Finally, it is concluded that S. brevipes possesses anti-inflammatory potential which validates the enthnomedicinal claim of the plant.

Item Description

10.3897/pharmacia.69.e82311
2603-557X