Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations

• Main Authors: Susbin Raj Wagle (Author), Bozica Kovacevic (Author), Daniel Walker (Author), Corina Mihaela Ionescu (Author), Melissa Jones (Author), Goran Stojanovic (Author), Sanja Kojic (Author), Armin Mooranian (Author), Hani Al-Salami (Author)
• Formato: Libro
• Publicado: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Summary

Bile acids have recently been studied for potential applications as formulation excipients and enhancers for drug release; however, some bile acids are not suitable for this application. Unconjugated lithocholic acid (ULCA) has recently shown drug formulation-stabilizing and anti-inflammatory effects. Lipophilic drugs have poor gut absorption after an oral dose, which necessitates the administration of high doses and causes subsequent side effects. Probucol (PB) is a highly lipophilic drug with poor oral absorption that resulted in restrictions on its clinical prescribing. Hence, this study aimed to design new delivery systems for PB using ULCA-based matrices and to test drug formulation, release, temperature, and biological effects. ULCA-based matrices were formulated for PB oral delivery by applying the jet-flow microencapsulation technique using sodium alginate as a polymer. ULCA addition to new PB matrices improved the microcapsule's stability, drug release <i>in vitro</i> (formulation study), and showed a promising effect in <i>ex vivo</i> study (<i>p</i> < 0.05), suggesting that ULCA can optimize the oral delivery of PB and support its potential application in diabetes treatment.

descrición da copia

10.3390/pharmaceutics12080708
1999-4923