Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors

• Asıl Yazarlar: Mona S. El-Zoghbi (Yazar), Samiha A. El-Sebaey (Yazar), Hanan A. AL-Ghulikah (Yazar), Eman A. Sobh (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

New thiazolopyrimidine derivatives 2, 3a-d, 4a-c, 5, 6a-c, and 7a,b were synthesised. All prepared compounds were evaluated by MTT cytotoxicity assay against three human tumour cell lines. Compounds 3c, 3d, 4c, 6a, 6b, and 7b exhibited potent to strong anticancer activity that was nearly comparable...