Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

• Main Authors: Akiyoshi Saitoh (Author), Yoshifumi Nagayama (Author), Daisuke Yamada (Author), Kosho Makino (Author), Toshinori Yoshioka (Author), Nanami Yamanaka (Author), Momoka Nakatani (Author), Yoshino Takahashi (Author), Mayuna Yamazaki (Author), Chihiro Shigemoto (Author), Misaki Ohashi (Author), Kotaro Okano (Author), Tomoki Omata (Author), Etsuko Toda (Author), Yoshitake Sano (Author), Hideyo Takahashi (Author), Kouji Matsushima (Author), Yuya Terashima (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism. However, a recent study has demonstrated that disulfiram also potently inhibits the cytoplasmic protein FROUNT, a common regulator of che...