Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach
Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide. A representative prodrug based...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2019-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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