Cover Image

Metabolomics Deciphers Potential Targets of Xuefu Zhuyu Decoction Against Traumatic Brain Injury in Rat

Xuefu Zhuyu decoction (XFZYD) performs multiple functions for traumatic brain injury (TBI) treatment. However, its clinical application is limited by the incomplete exploration of targets and inadequate discussion of mechanisms. We aimed to investigate the metabolic alterations of XFZYD in acute and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Teng Li (Author), En Hu (Author), Pengfei Li (Author), Zhaoyu Yang (Author), Yao Wu (Author), Ruoqi Ding (Author), Xiaofei Zhu (Author), Tao Tang (Author), Yang Wang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2020-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Metabolomics integrated with network pharmacology of blood-entry constituents reveals the bioactive component of Xuefu Zhuyu decoction and its angiogenic effects in treating traumatic brain injury
by: Teng Li, et al.
Published: (2024)

Bioinformatics Analysis of miRNAs and mRNAs Network-Xuefu Zhuyu Decoction Exerts Neuroprotection of Traumatic Brain Injury Mice in the Subacute Phase
by: Zhao-yu Yang, et al.
Published: (2022)

Network pharmacological analysis of Xuefu Zhuyu decoction in the treatment of atherosclerosis
by: Jinxia Yuan, et al.
Published: (2022)

Metabolic Profiling Analysis of Patients With Coronary Heart Disease Undergoing Xuefu Zhuyu Decoction Treatment
by: Tianqi Tao, et al.
Published: (2019)

XuefuZhuyu decoction protected cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy
by: Xiaowen Shi, et al.
Published: (2017)

Analysis of the Anti-Tumour Effect of Xuefu Zhuyu Decoction Based on Network Pharmacology and Experimental Verification in Drosophila
by: Sitong Wang, et al.
Published: (2022)

The mechanisms underlying the actions of Xuefu Zhuyu decoction pretreatment against neurological deficits after ischemic stroke in mice: The mediation of glymphatic function by aquaporin-4 and its anchoring proteins
by: Ting Yi, et al.
Published: (2022)

Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury
by: En Hu, et al.
Published: (2023)

Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke
by: Lingling Yang, et al.
Published: (2022)

Exploration of Potential Therapeutic Targets of Shentong Zhuyu Decoction for Ankylosing Spondylitis Based on Network Pharmacology and Molecular Docking
by: Xin H, et al.
Published: (2024)

Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction
by: Boyu Pan, et al.
Published: (2022)

Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation
by: Guo Y, et al.
Published: (2023)

Deciphering the active constituents of Dabushen decoction of ameliorating osteoarthritis via PPARγ preservation by targeting DNMT1
by: Lu Qiu, et al.
Published: (2022)

Mechanism of interventional effect and targets of Zhuyu pill in regulating and suppressing colitis and cholestasis
by: Han Yu, et al.
Published: (2022)

Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress
by: Xiaofei Zhu, et al.
Published: (2022)

Deciphering the Pharmacological Mechanisms of Ma Xing Shi Gan Decoction against COVID-19 through Integrating Network Pharmacology and Experimental Exploration
by: Qianqian Li, et al.
Published: (2020)

Omics for deciphering oral microecology
by: Yongwang Lin, et al.
Published: (2024)

Deciphering potential pharmacological mechanism of Sha-Shen-Mai-Dong decoction on primary Sjogren's syndrome
by: Yuepeng Jiang, et al.
Published: (2021)

The zhuyu pill relieves rat cholestasis by regulating the mRNA expression of lipid and bile metabolism associated genes
by: Jun Han, et al.
Published: (2023)

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics
by: Shu-Yue Qu, et al.
Published: (2021)

Non-Targeted Metabolomic Profiling of Coronary Heart Disease Patients With Taohong Siwu Decoction Treatment
by: Tianqi Tao, et al.
Published: (2020)

Shizao decoction for cirrhotic ascites: assessing potential targets based on network analysis combined with pharmacokinetics and metabolomics
by: Wenjing Li, et al.
Published: (2024)

Effects and Potential Mechanism of Zhuyu Pill Against Atherosclerosis: Network Pharmacology and Experimental Validation
by: Pan Y, et al.
Published: (2023)

Efficacy of Zhuyu Pill Intervention in a Cholestasis Rat Model: Mutual Effects on Fecal Metabolism and Microbial Diversity
by: Han Yu, et al.
Published: (2021)

Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics
by: Rui-Pei Yang, et al.
Published: (2021)

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis
by: Liang J, et al.
Published: (2021)

The Interventional Effects of Tubson-2 Decoction on Ovariectomized Rats as Determined by a Combination of Network Pharmacology and Metabolomics
by: Fan Yang, et al.
Published: (2020)

Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo
by: Shanshan Zhou, et al.
Published: (2020)

Study on the Immunomodulatory effect of Qixian Decoction in an Asthmatic Mice Model Based on Serum Metabolomics
by: Manman Li, et al.
Published: (2024)

Metabolomics Profiles Reveal the Efficacy of Wuzhuyu Decoction on Patients with Chronic Non-Atrophic Gastritis
by: Hu Q, et al.
Published: (2023)

Hu'po Anshen Decoction Accelerated Fracture-Healing in a Rat Model of Traumatic Brain Injury Through Activation of PI3K/AKT Pathway
by: Jing Shen, et al.
Published: (2022)

Gut microbes combined with metabolomics reveal the protective effects of Qijia Rougan decoction against CCl4-induced hepatic fibrosis
by: Xue Li, et al.
Published: (2024)

Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease
by: Panpan Chen, et al.
Published: (2024)

Biomarkers for the Clinical Diagnosis of Alzheimer's Disease: Metabolomics Analysis of Brain Tissue and Blood
by: Yang-Yang Wang, et al.
Published: (2021)

Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy
by: Xu Cao, et al.
Published: (2022)

Microbiome Metabolomic Analysis of the Anxiolytic Effect of Baihe Dihuang Decoction in a Rat Model of Chronic Restraint Stress
by: Tang L, et al.
Published: (2024)

Exploring the mechanism of Taohong Siwu Decoction on the treatment of blood deficiency and blood stasis syndrome by gut microbiota combined with metabolomics
by: Yao He, et al.
Published: (2023)

Deciphering the decisive factors driving fate bifurcations in somatic cell reprogramming
by: Chunshen Long, et al.
Published: (2023)

Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice
by: Jianguo Xu, et al.
Published: (2013)

High-Throughput Metabolomics for Identification of Metabolic Pathways and Deciphering the Effect Mechanism of Dioscin on Rectal Cancer From Cell Metabolic Profiles Coupled With Chemometrics Analysis
by: Xin-Xin Wang, et al.
Published: (2020)