β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability
β-carotene, precursor of vitamin A, is an excellent antioxidant with many beneficial properties. It is a lipid-soluble antioxidant and a very effective quencher of reactive oxygen species (ROS) to reduce the oxidative stress. In contrast to vitamin A, β-carotene is not toxic even consumed in higher...
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Frontiers Media S.A.,
2021-02-01T00:00:00Z.
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| 001 | doaj_68c4d87e18b34bc4b2de5c8da6e8d8a6 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Dongxue Ma |e author |
| 700 | 1 | 0 | |a Pengfei Han |e author |
| 700 | 1 | 0 | |a Mingji Song |e author |
| 700 | 1 | 0 | |a Hongfu Zhang |e author |
| 700 | 1 | 0 | |a Wei Shen |e author |
| 700 | 1 | 0 | |a Guian Huang |e author |
| 700 | 1 | 0 | |a Minghui Zhao |e author |
| 700 | 1 | 0 | |a Qingyuan Sun |e author |
| 700 | 1 | 0 | |a Yong Zhao |e author |
| 700 | 1 | 0 | |a Yong Zhao |e author |
| 700 | 1 | 0 | |a Lingjiang Min |e author |
| 245 | 0 | 0 | |a β-carotene Rescues Busulfan Disrupted Spermatogenesis Through Elevation in Testicular Antioxidant Capability |
| 260 | |b Frontiers Media S.A., |c 2021-02-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2021.593953 | ||
| 520 | |a β-carotene, precursor of vitamin A, is an excellent antioxidant with many beneficial properties. It is a lipid-soluble antioxidant and a very effective quencher of reactive oxygen species (ROS) to reduce the oxidative stress. In contrast to vitamin A, β-carotene is not toxic even consumed in higher amount when it is delivered from natural plant products. Recently, we found that β-carotene acts as a potential antioxidant in the oocyte to improve its quality. Even though many studies have been reported that β-carotene has the beneficial contribution to the ovarian development and steroidogenesis, it is unknown the effects of β-carotene on the spermatogenesis. This investigation aimed to explore the hypothesis that β-carotene could improve spermatogenesis and the underlying mechanism. And we found that β-carotene rescued busulfan disrupted spermatogenesis in mouse with the increase in the sperm concentration and motility. β-carotene improved the expression of genes/proteins important for spermatogenesis, such as VASA, DAZL, SYCP3, PGK2. Moreover, β-carotene elevated the testicular antioxidant capability by the elevation of the antioxidant glutathione and antioxidant enzymes SOD, GPX1, catalase levels. In conclusion, β-carotene may be applied for the infertile couples by the improvement of spermatogenesis, since, worldly many couples are infertile due to the idiopathic failed gametogenesis (spermatogenesis). | ||
| 546 | |a EN | ||
| 690 | |a β-carotene | ||
| 690 | |a spermatogenesis | ||
| 690 | |a antioxidant | ||
| 690 | |a improvement | ||
| 690 | |a reactive oxygen species | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 12 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2021.593953/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/68c4d87e18b34bc4b2de5c8da6e8d8a6 |z Connect to this object online. |