Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

• المؤلفون الرئيسيون: James Cobley (مؤلف), Anna Noble (مؤلف), Rachel Bessell (مؤلف), Matthew Guille (مؤلف), Holger Husi (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2020-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive ATP synthase activity is significa...