Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

• Autori principali: James Cobley (Autore), Anna Noble (Autore), Rachel Bessell (Autore), Matthew Guille (Autore), Holger Husi (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive ATP synthase activity is significa...