Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

• Những tác giả chính: James Cobley (Tác giả), Anna Noble (Tác giả), Rachel Bessell (Tác giả), Matthew Guille (Tác giả), Holger Husi (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2020-03-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive ATP synthase activity is significa...