Differential Expression of Platelet Glycoprotein Ia/IIa in Taiwan Chinese Corresponds to Glycoprotein Ia Gene Polymorphisms
Abstract.: Glycoprotein (GP) Ia/IIa plays a key role in platelet function by acting as a primary receptor for subendothelial collagen, thereby contributing to arterial thrombosis. In this study, we found that the expression level of platelet GPIa/IIa among Taiwan Chinese varies over sixfold and this...
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| Format: | Book |
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Elsevier,
2006-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_690b3d4ebb7e4bfaba4fc91feaa5a795 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Liu Chao-Zong |e author |
| 700 | 1 | 0 | |a Wang Yi-Chai |e author |
| 700 | 1 | 0 | |a Wang Ji-Hung |e author |
| 700 | 1 | 0 | |a Shaw Cheng-Kuang |e author |
| 700 | 1 | 0 | |a Lin Gang-Ling |e author |
| 245 | 0 | 0 | |a Differential Expression of Platelet Glycoprotein Ia/IIa in Taiwan Chinese Corresponds to Glycoprotein Ia Gene Polymorphisms |
| 260 | |b Elsevier, |c 2006-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.sc0050174 | ||
| 520 | |a Abstract.: Glycoprotein (GP) Ia/IIa plays a key role in platelet function by acting as a primary receptor for subendothelial collagen, thereby contributing to arterial thrombosis. In this study, we found that the expression level of platelet GPIa/IIa among Taiwan Chinese varies over sixfold and this difference relates either to the GPIa gene 807 C/T dimorphisms or the appearance of BglII restriction sequence within intron G. This is the first study to demonstrate the wide variation of platelet GPIa/IIa density in an Oriental population and its correlation to the GPIa gene polymorphisms. These results provide useful tools for predicting platelet GPIa/IIa density of Chinese. Keywords:: collagen, glycoprotein Ia/IIa density, glycoprotein Ia gene polymorphism | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 101, Iss 1, Pp 103-106 (2006) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319344810 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/690b3d4ebb7e4bfaba4fc91feaa5a795 |z Connect to this object online. |