The Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis

• المؤلفون الرئيسيون: Jhohann Richard de Lima Benzi (مؤلف), Patrícia Pereira dos Santos Melli (مؤلف), Geraldo Duarte (مؤلف), Jashvant D. Unadkat (مؤلف), Vera Lucia Lanchote (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact of inflammation on renal drug transporters remains to be elucidated. We aimed to quantify the effect of inflammation (caused by acute pyelonephritis) on the in vivo activity of renal OAT1/3, using the probe drug f...