Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete <i>Dentipellis fragilis</i>
In our continued search for biologically active metabolites from cultures of rare Basidiomycota species, we found eight previously undescribed cyathane-xylosides from submerged cultures of <i>Dentipellis fragilis</i>, which were named dentifragilins A-H. In addition, the known cyathane d...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2022-08-01T00:00:00Z.
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| Summary: | In our continued search for biologically active metabolites from cultures of rare Basidiomycota species, we found eight previously undescribed cyathane-xylosides from submerged cultures of <i>Dentipellis fragilis</i>, which were named dentifragilins A-H. In addition, the known cyathane derivatives striatal D and laxitextine A were isolated. All compounds were characterized by high-resolution electrospray ionization mass spectrometry (HR-ESIMS) as well as by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Several of the compounds exhibited significant activities in standardized cell-based assays for the determination of antimicrobial and cytotoxic effects. The discovery of cyathanes in the genus <i>Dentipellis</i> has chemotaxonomic implications, as this class of diterpenoids has already been shown to be characteristic for mycelial cultures of the related genera <i>Hericium</i> and <i>Laxitextum</i>, which are classified as <i>Dentipellis</i> in the family Hericiaceae. |
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| Item Description: | 10.3390/antibiotics11081072 2079-6382 |