Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes

Drug delivery systems are believed to increase pharmaceutical efficacy and the therapeutic index by protecting and stabilizing bioactive molecules, such as protein and peptides, against body fluids' enzymes and/or unsuitable physicochemical conditions while preserving the surrounding healthy ti...

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Main Authors: Raiane Vieira Cardoso (Author), Patricia Ribeiro Pereira (Author), Cyntia Silva Freitas (Author), Vania Margaret Flosi Paschoalin (Author)
Format: Book
Published: MDPI AG, 2022-12-01T00:00:00Z.
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100 1 0 |a Raiane Vieira Cardoso  |e author 
700 1 0 |a Patricia Ribeiro Pereira  |e author 
700 1 0 |a Cyntia Silva Freitas  |e author 
700 1 0 |a Vania Margaret Flosi Paschoalin  |e author 
245 0 0 |a Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes 
260 |b MDPI AG,   |c 2022-12-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics14122808 
500 |a 1999-4923 
520 |a Drug delivery systems are believed to increase pharmaceutical efficacy and the therapeutic index by protecting and stabilizing bioactive molecules, such as protein and peptides, against body fluids' enzymes and/or unsuitable physicochemical conditions while preserving the surrounding healthy tissues from toxicity. Liposomes are biocompatible and biodegradable and do not cause immunogenicity following intravenous or topical administration. Still, their most important characteristic is the ability to load any drug or complex molecule uncommitted to its hydrophobic or hydrophilic character. Selecting lipid components, ratios and thermo-sensitivity is critical to achieve a suitable nano-liposomal formulation. Nano-liposomal surfaces can be tailored to interact successfully with target cells, avoiding undesirable associations with plasma proteins and enhancing their half-life in the bloodstream. Macropinocytosis-dynamin-independent, cell-membrane-cholesterol-dependent processes, clathrin, and caveolae-independent mechanisms are involved in liposome internalization and trafficking within target cells to deliver the loaded drugs to modulate cell function. A successful translation from animal studies to clinical trials is still an important challenge surrounding the approval of new nano-liposomal drugs that have been the focus of investigations. Precision medicine based on the design of functionalized nano-delivery systems bearing highly specific molecules to drive therapies is a promising strategy to treat degenerative diseases. 
546 |a EN 
690 |a nano-delivery systems 
690 |a liposomal formulations 
690 |a liposomal marketed formulations 
690 |a liposome-cell interaction 
690 |a protein and peptide encapsulation 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 14, Iss 12, p 2808 (2022) 
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