Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs

• Asıl Yazarlar: Rohan Kalyan Rej (Yazar), Srinivasa Rao Allu (Yazar), Joyeeta Roy (Yazar), Ranjan Kumar Acharyya (Yazar), I. N. Chaithanya Kiran (Yazar), Yesu Addepalli (Yazar), V. Dhamodharan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2024-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show promise to open a target space not accessible to conventional small molecules via a degradation-based mechanism. PROTAC degraders, due to their bifunctional nature, which is categorized as 'beyond the Rule o...