A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer

• Main Authors: Xinhua Zhou (Author), Anqi Wang (Author), Liang Wang (Author), Jianhua Yin (Author), Li Wang (Author), Lijun Di (Author), Maggie Pui-Man Hoi (Author), Luchen Shan (Author), Xu Wu (Author), Yuqiang Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: We previously demonstrated that a Danshensu-Tetramethylpyrazine conjugate DT-010 enhanced anticancer effect of doxorubicin (Dox) in Dox-sensitive human breast cancer cells, and protected against Dox-induced cardiotoxicity. This work was designed to see whether DT-010 overcomes Dox resist...