Modeling hematopoietic disorders in zebrafish
Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blo...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2019-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research. |
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| Item Description: | 1754-8403 1754-8411 10.1242/dmm.040360 |