Machine-Learning Exploration of Exposure-Effect Relationships of Cisplatin in Head and Neck Cancer Patients

• Main Authors: Céleste Cauvin (Author), Laurent Bourguignon (Author), Laure Carriat (Author), Abel Mence (Author), Pauline Ghipponi (Author), Sébastien Salas (Author), Joseph Ciccolini (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Cisplatin is a pivotal drug in the treatment of head and neck cancer, and personalized dosage should help the preservation of an optimal toxicity-efficacy ratio. Methods: We analyzed the exposure-effect relationships of 80 adult patients with head and neck cancers and treated with standa...