Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range

• Main Authors: Joerg Berghausen (Author), Frank Hans Seiler (Author), Nathalie Gobeau (Author), Bernard Faller (Author)
• Format: Bog
• Udgivet: International Association of Physical Chemists (IAPC), 2016-03-01T00:00:00Z.
• Fag: article
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Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility. Biorelevant media of the fasted and fed state have been published for humans, as well as for dogs in the fasted st...