Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range

• Κύριοι συγγραφείς: Joerg Berghausen (Συγγραφέας), Frank Hans Seiler (Συγγραφέας), Nathalie Gobeau (Συγγραφέας), Bernard Faller (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: International Association of Physical Chemists (IAPC), 2016-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility. Biorelevant media of the fasted and fed state have been published for humans, as well as for dogs in the fasted st...