Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range

• Главные авторы: Joerg Berghausen (Автор), Frank Hans Seiler (Автор), Nathalie Gobeau (Автор), Bernard Faller (Автор)
• Формат: ‌
• Опубликовано: International Association of Physical Chemists (IAPC), 2016-03-01T00:00:00Z.
• Предметы: article
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Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility. Biorelevant media of the fasted and fed state have been published for humans, as well as for dogs in the fasted st...