AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

• Autores principales: Aijaz Ahmad John (Autor), Jun Xie (Autor), Yeon-Suk Yang (Autor), Jung-Min Kim (Autor), Chujiao Lin (Autor), Hong Ma (Autor), Guangping Gao (Autor), Jae-Hyuck Shim (Autor)
• Formato: Libro
• Publicado: Elsevier, 2022-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited therapeutic effects because osteoblast-mediated bone f...