AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

• Main Authors: Aijaz Ahmad John (Author), Jun Xie (Author), Yeon-Suk Yang (Author), Jung-Min Kim (Author), Chujiao Lin (Author), Hong Ma (Author), Guangping Gao (Author), Jae-Hyuck Shim (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited therapeutic effects because osteoblast-mediated bone f...