Irinotecan Activates p53 With Its Active Metabolite, Resulting in Human Hepatocellular Carcinoma Apoptosis
The topoisomerase I inhibitor irinotecan is widely used in anticancer therapy, although the detailed mechanism is still unclear. We investigated the apoptotic mechanisms of irinotecan in human hepatocellular carcinoma (HCC) cell lines (Huh7). SN-38 caused a significant decrease in cell proliferation...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2007-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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