Irinotecan Activates p53 With Its Active Metabolite, Resulting in Human Hepatocellular Carcinoma Apoptosis

• Main Authors: Yuko Takeba (Author), Toshio Kumai (Author), Naoki Matsumoto (Author), Sachiko Nakaya (Author), Yoshimitsu Tsuzuki (Author), Yohei Yanagida (Author), Shinichi Kobayashi (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The topoisomerase I inhibitor irinotecan is widely used in anticancer therapy, although the detailed mechanism is still unclear. We investigated the apoptotic mechanisms of irinotecan in human hepatocellular carcinoma (HCC) cell lines (Huh7). SN-38 caused a significant decrease in cell proliferation...