Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior

• Main Authors: Fushen Zhang (Author), Shihao Huang (Author), Haiyan Bu (Author), Yu Zhou (Author), Lixiang Chen (Author), Ziliu Kang (Author), Liangpei Chen (Author), He Yan (Author), Chang Yang (Author), Jie Yan (Author), Xiaohong Jian (Author), Yixiao Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking. The mammalian target of rapamycin signaling pathway is involved in reconsol...