Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure

• Main Authors: Zhou Sirui (Author), Yang Lu (Author), Wang Jing (Author), Wang Binbin (Author), Suo Peisu (Author), Chen Beili (Author), Zhu Ying (Author), Ma Xu (Author), Cao Yunxia (Author)
• Format: Book
• Published: BMC, 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>The <it>WNT4 </it>gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles.</p> <p>Methods</p> <p>We sequenced the coding region and splice sites of <it>WNT4 </it>in 145 Han Chinese women with premature ovarian failure (POF) and 200 healthy controls.</p> <p>Results</p> <p>Only one novel variation, in Exon 2 (195C > T), was detected among the women with POF. However, this synonymous variation did not result in a change in amino acid sequence (65 Asp > Asp). No further variants were found in any of the samples.</p> <p>Conclusion</p> <p>Although we cannot provide any evidence that it is a possible disease-causing gene, this study is the first attempt to investigate the possible role of <it>WNT4 </it>in Han Chinese women with POF.</p>

Item Description

10.1186/1477-7827-9-75
1477-7827