Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors

• Autors principals: Tarek S. Ibrahim (Autor), Azizah M. Malebari (Autor), Mamdouh F. A. Mohamed (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2021-11-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Recently, combining histone deacetylase (HDAC) inhibitors with chemotherapeutic drugs or agents, in particular epidermal growth factor receptor (EGFR) inhibitors, is considered to be one of the most encouraging strategy to enhance the efficacy of the antineoplastic agents and decrease or avoid drug...