Synthesis, Anti-Tumor Activity and Apoptosis-Inducing Effect of Novel Dimeric Keggin-Type Phosphotungstate
A dimeric Keggin-type phosphotungstate (ODA)10[(PW11FeO39)2O]·9H2O (abbreviated as ODA10[(PW11Fe)2], ODA = octadecyltrimethylammonium bromide) was synthesized and investigated comprehensively its antitumor activity on MCF-7 and A549 cells. The dimeric structure and amorphous morphology were characte...
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Frontiers Media S.A.,
2021-01-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yingxue Xue |e author |
| 700 | 1 | 0 | |a Yifei Yin |e author |
| 700 | 1 | 0 | |a He Li |e author |
| 700 | 1 | 0 | |a Mingyu Chi |e author |
| 700 | 1 | 0 | |a Jiaxin Guo |e author |
| 700 | 1 | 0 | |a Guihua Cui |e author |
| 700 | 1 | 0 | |a Wenliang Li |e author |
| 700 | 1 | 0 | |a Wenliang Li |e author |
| 245 | 0 | 0 | |a Synthesis, Anti-Tumor Activity and Apoptosis-Inducing Effect of Novel Dimeric Keggin-Type Phosphotungstate |
| 260 | |b Frontiers Media S.A., |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2020.632838 | ||
| 520 | |a A dimeric Keggin-type phosphotungstate (ODA)10[(PW11FeO39)2O]·9H2O (abbreviated as ODA10[(PW11Fe)2], ODA = octadecyltrimethylammonium bromide) was synthesized and investigated comprehensively its antitumor activity on MCF-7 and A549 cells. The dimeric structure and amorphous morphology were characterized by FT-IR, UV-vis-DRS, SEM and XRD. The in vitro MTT assay of ODA10[(PW11Fe)2] showed anticancer activity on MCF-7 and A549 cells in a dose- and time-dependent manner, and the IC50 values for MCF-7 and A549 cells at 48 h were 5.83 μg/ml and 3.23 μg/ml, respectively. The images of the ODA10[(PW11Fe)2]-treated cells observed by inverted biological microscope exhibited the characteristic morphology of apoptosis. Flow cytometric analysis showed cell apoptosis and cycle arrested at S phase induced by ODA10[(PW11Fe)2]. The above results illuminated the main mechanism of the antitumor action of ODA10[(PW11Fe)2] on MCF-7 and A549 cells, indicating that this dimeric phosphotungstate is a promising anticancer drug. | ||
| 546 | |a EN | ||
| 690 | |a anti-tumor | ||
| 690 | |a apoptosis | ||
| 690 | |a dimeric | ||
| 690 | |a Keggin-type | ||
| 690 | |a phosphotungstate | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 11 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2020.632838/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6b2bf1c1a25a4c518c2492cb0c94b44f |z Connect to this object online. |