Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs

• Main Authors: Hiroshi Iwasaki (Author), Akira Takahara (Author), Yuji Nakamura (Author), Yoshioki Satoh (Author), Takeshi Nagai (Author), Norihiro Shinkai (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects were simultaneously assessed using chronic atrioventricular block dogs. After application of the patch (9.8 mg/kg), pilsicainide was continuously absorbed through the skin with a Cmax of 0.49 ± 0.13...