Notch activation promotes endothelial quiescence by repressing MYC expression via miR-218

• Main Authors: Jia-Xing Sun (Author), Guo-Rui Dou (Author), Zi-Yan Yang (Author), Liang Liang (Author), Juan-Li Duan (Author), Bai Ruan (Author), Man-Hong Li (Author), Tian-Fang Chang (Author), Xin-Yuan Xu (Author), Juan-Juan Chen (Author), Yu-Sheng Wang (Author), Xian-Chun Yan (Author), Hua Han (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

After angiogenesis-activated embryonic and early postnatal vascularization, endothelial cells (ECs) in most tissues enter a quiescent state necessary for proper tissue perfusion and EC functions. Notch signaling is essential for maintaining EC quiescence, but the mechanisms of action remain elusive....