HIV-1 RT-Associated RNase H review
HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently,...
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| Main Authors: | , , |
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| Format: | Book |
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Ain Shams University,
2018-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors. |
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| Item Description: | https://dx.doi.org/10.21608/aps.2018.18731 2356-8380 2356-8399 |