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A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides

Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20&#8722;200 <i>n</i>) and the same lengths routine poly(dNTP) and poly(NTP) species were tested for their impact on catalytic activities of &#946;-like DNA polymerases from chromatin of...

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Main Authors: Sergey Stovbun (Author), Kirill Ermakov (Author), Alexander Bukhvostov (Author), Alexander Vedenkin (Author), Dmitry Kuznetsov (Author)
Format: Book
Published: MDPI AG, 2019-10-01T00:00:00Z.
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Summary:Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20&#8722;200 <i>n</i>) and the same lengths routine poly(dNTP) and poly(NTP) species were tested for their impact on catalytic activities of &#946;-like DNA polymerases from chromatin of HL-60, WERI-1A and Y-79 cells as well as for the affinity patterns in DNApol&#946;-poly(dNTP)/(NTP) pairs, respectively. An essential link between the lengths of ultrashort (50&#8722;100 <i>n</i>) single-stranded poly(dNTP) sequences of different structures and their inhibitory effects towards the cancer-specific DNA polymerases &#946; was found. A possible significance of this phenomenon for both DNA repair suppression in tumors and a consequent anti-cancer activity of the DNA repair related short poly(dNTP) fragments is under discussion.
Item Description:2218-0532
10.3390/scipharm87040025

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