Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Its Neuroinflammation, Synaptic Dysplasticity and Apoptosis

• Main Authors: Medhat Taha (Author), Sara T. Elazab (Author), Alaa. M. Badawy (Author), Abdullah A. Saati (Author), Naeem F. Qusty (Author), Abdullah G. Al-Kushi (Author), Anas Sarhan (Author), Amira Osman (Author), Amira E. Farage (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemo fog is one of the most serious health concerns encountered by cancer survivors receiving doxorubicin (DOX)-based chemotherapy. Oxidative stress, neuroinflammation, apoptosis and impairment of synaptic plasticity are regarded as the key factors implicated in DOX-induced cognitive impairment. Th...