CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS

The aim of the present work was to prepare hydrogel matrix tablets using crosslinked chitosan and hydroxyethyl cellulose (HEC) for controlled release of gabapentin. The chitosan was crosslinked with acetaldehyde and used for the preparation of hydrogel matrix tablets along with hydroxylethyl cellulo...

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Main Authors: Narasimha S. Managoli (Author), Raghavendra V. Kulkarni (Author), Nadendla Ramarao (Author), Iranna S. Muchandi (Author)
Format: Book
Published: Universitas Gadjah Mada, 2014-07-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Narasimha S. Managoli  |e author 
700 1 0 |a Raghavendra V. Kulkarni  |e author 
700 1 0 |a Nadendla Ramarao  |e author 
700 1 0 |a Iranna S. Muchandi  |e author 
245 0 0 |a CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS 
260 |b Universitas Gadjah Mada,   |c 2014-07-01T00:00:00Z. 
500 |a 10.14499/indonesianjpharm25iss3pp164 
500 |a 2338-9427 
500 |a 2338-9486 
520 |a The aim of the present work was to prepare hydrogel matrix tablets using crosslinked chitosan and hydroxyethyl cellulose (HEC) for controlled release of gabapentin. The chitosan was crosslinked with acetaldehyde and used for the preparation of hydrogel matrix tablets along with hydroxylethyl cellulose by wet granulation method. The samples were characterized by FTIR, DSC, TGA, XRD, SEM and evaluated drug content, swelling pattern and drug release. The matrix tablets were capable of releasing the drug for 24h depending upon the formulation variables. It was observed that as the concentration of HEC increased in the tablets, the drug release was also increased. On the other hand, as the crosslinking of chitosan was increased, the drug release was decreased. Drug release mechanism followed non-Fickian transport. This study demonstrated that the blend hydrogel matrix tablets of crosslinked chitosan and HEC could be a versatile drug delivery system for controlled release of gabapentin. 
546 |a EN 
690 |a : tr crosslinked chitosan 
690 |a hydroxyethyl cellulose 
690 |a hydrogel tablets 
690 |a controlled release 
690 |a gabapentin 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Indonesian Journal of Pharmacy, Vol 25, Iss 3, Pp 164-173 (2014) 
787 0 |n http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/219 
787 0 |n https://doaj.org/toc/2338-9427 
787 0 |n https://doaj.org/toc/2338-9486 
856 4 1 |u https://doaj.org/article/6c1a35a4cd3b405c93d511a28ca5f06f  |z Connect to this object online.