Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice

• Main Authors: Yu Zhang (Author), Xiaodong Xi (Author), Hang Yu (Author), Liuyan Yang (Author), Jinzhong Lin (Author), Wen Yang (Author), Junling Liu (Author), Xuemei Fan (Author), Yingjie Xu (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of messenger RNA (mRNA) enables the transient production of therapeutic proteins with stable and predictable translational kinetics and without the risk of insertional mutagenesis. Recent findings highlight the enormous potential of mRNA-based therapeutics. Here, we describe the synthesis of...