Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis

• Main Authors: Ting Zhou (Author), Lan lin (Author), Yawen Zhan (Author), Ziyao Zhang (Author), Ying Jiang (Author), Mi Wu (Author), Dan Xue (Author), Limin Chen (Author), Xiufang Weng (Author), Zhenghui Huang (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The development of pulmonary fibrosis involves a cascade of events, in which inflammation mediated by immune cells plays a pivotal role. Chemotherapeutic drugs have been shown to have dual effects on fibrosis, with bleomycin exacerbating pulmonary fibrosis and bortezomib alleviat...