REGULATION OF DROSOPHILA INTESTINAL STEM CELL MAINTENANCE AND PROLIFERATION
To<strong> </strong>maintain gut homeostasis intestinal stem cells (ISCs) constantly replace damaged ones. This process is conservative from <em>Drosophila</em> to human. Proliferation and differentiation of ISCs in adult <em>Drosophila</em> midgut are regulated b...
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Published: |
Vasyl Stefanyk Precarpathian National University,
2015-05-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | To<strong> </strong>maintain gut homeostasis intestinal stem cells (ISCs) constantly replace damaged ones. This process is conservative from <em>Drosophila</em> to human. Proliferation and differentiation of ISCs in adult <em>Drosophila</em> midgut are regulated by growth factors which are secreted in the surrounding cells collectively forming ISCs niche. Here I discuss an interaction between ISCs with its niche through conservative signaling pathways. Several evidences on significance of cooperation between multiple signaling pathways including Notch, Wingless, JAK/STAT, EGFR, Hippo, and insulin signaling for regulation of stem cell maintenance and activity are provided. Further investigation in this area will allow us to understand how proper regulation of ISCs maintenance and differentiation can assist to ensure intestinal integrity. |
|---|---|
| Item Description: | 2311-0155 2413-2349 10.15330/jpnu.2.1.77-84 |