Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14

• Egile Nagusiak: Lucía Sanjurjo (Egilea), Esmeralda Castelblanco (Egilea), Josep Julve (Egilea), Nuria Villalmanzo (Egilea), Érica Téllez (Egilea), Anna Ramirez-Morros (Egilea), Núria Alonso (Egilea), Dídac Mauricio (Egilea), Maria-Rosa Sarrias (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Atherosclerosis, a process in which macrophages play a key role, is accelerated in diabetes. Elevated concentrations of serum-oxidized low-density lipoproteins (oxLDL) represent a common feature of both conditions. The main goal of this study was to determine the contribution of oxLDL to the inflamm...