Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives
Abstract Background For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In a search of new antimicrobial agents, a series of new steroidal hydrazones were designed and synthesized. Result Th...
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2022-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_6cb81186bb7044e4b8ba8bb7da9c7ea4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shailesh Mistry |e author |
| 700 | 1 | 0 | |a Akhilesh Kumar Singh |e author |
| 245 | 0 | 0 | |a Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives |
| 260 | |b SpringerOpen, |c 2022-01-01T00:00:00Z. | ||
| 500 | |a 10.1186/s43094-021-00391-4 | ||
| 500 | |a 2314-7253 | ||
| 520 | |a Abstract Background For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In a search of new antimicrobial agents, a series of new steroidal hydrazones were designed and synthesized. Result The structures of the compounds were established based on the spectral data. The in vitro antimicrobial activity of some newly synthesized compounds against bacteria and fungi was studied. Conclusion New compounds showed better or similar antimicrobial activity. Designing more efficient steroidal hydrazones from ketosteroid based on the current study may successfully lead to the development of antimicrobial agent. Graphical abstract | ||
| 546 | |a EN | ||
| 690 | |a Androstene | ||
| 690 | |a Estrane | ||
| 690 | |a Hydralazine hydrochloride | ||
| 690 | |a Hydrazone | ||
| 690 | |a Antimicrobial activity | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Future Journal of Pharmaceutical Sciences, Vol 8, Iss 1, Pp 1-10 (2022) | |
| 787 | 0 | |n https://doi.org/10.1186/s43094-021-00391-4 | |
| 787 | 0 | |n https://doaj.org/toc/2314-7253 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6cb81186bb7044e4b8ba8bb7da9c7ea4 |z Connect to this object online. |