Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)

• Main Authors: Andrich Jürgen (Author), Saft Carsten (Author), Kraus Peter H (Author), Arning Larissa (Author), Epplen Jörg T (Author)
• Format: Book
• Published: BMC, 2005-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p><it>TP53 </it>is an attractive candidate for modifying age of onset (AO) in Huntington disease (HD): The amino-terminus of the mutated huntingtin (htt) exon 1 translation product has functional properties which may affect...