Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats
Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of...
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Elsevier,
2018-11-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_6cf969da8a3a4d84b61e23f77ca5b2c1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Shota Yamamoto |e author |
| 700 | 1 | 0 | |a Nobuaki Egashira |e author |
| 700 | 1 | 0 | |a Makoto Tsuda |e author |
| 700 | 1 | 0 | |a Satohiro Masuda |e author |
| 245 | 0 | 0 | |a Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats |
| 260 | |b Elsevier, |c 2018-11-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2018.10.006 | ||
| 520 | |a Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of riluzole on oxaliplatin-induced cold allodynia. In cultured DRG neurons, riluzole suppressed oxalate-induced increase of the number of menthol (TRPM8 agonist)-sensitive cells. Moreover, riluzole prevented cold allodynia and increase in levels of TRPM8 mRNA in oxaliplatin-treated rats. These results suggest that riluzole prevents oxaliplatin-induced cold allodynia via inhibition of TRPM8 overexpression in the DRG. Keywords: Oxaliplatin-induced cold allodynia, Riluzole, TRPM8 | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 214-217 (2018) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861318301920 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/6cf969da8a3a4d84b61e23f77ca5b2c1 |z Connect to this object online. |